Pre-implantation genetic screening-PGS (also known as aneuploidy screening)
involves checking the chromosomes of embryos conceived by in vitro
fertilisation (IVF) or intra-cytoplasmic sperm injection (ICSI) for common
abnormalities. This avoids having abnormal embryos transferred to the womb
during IVF or ICSI. PGS is accomplished as part of the in vitro fertilization
(IVF) process, commonly used to treat infertile couples. But, in this case, the
embryos are tested for the presence or absence of specific chromosomal
abnormalities prior to transfer into the uterus (IVF-PGS).
The Embryology IVF laboratory has to be designed in such a way that it
provides an environment that is as close to optimum as possible for the growth
of human embryos and to provide the best resulting pregnancy rates for patients
undergoing IVF treatment or cycles. For the success of any infertility or
fertility clinic the inbuilt ivf laboratory plays an important role. IVF
laboratory is the key to success in In Vitro Fertilisation (IVF) clinic.
Maintaining air quality control is the biggest challenge for all IVF
laboratories and IVF clinics. Embryos and specimens may be subjected to
unforeseen and unexpected harsh environmental contamination such as mix of
dust, pesticides, fire smoke, volcanic ash, mold, and bacteria. Apart from
maintaining high level of air quality, experience of Fertility specialists,
Fertility embryologists and scientists are the key factors to be kept in mind
for the success of any IVF lab.
The IVF Lab Facility is the most critical work area in the entire ART
Centre. In this area sperm, embryos and Oocytes are manipulated openly after
following disinfection and sterilization steps. Pre implantation genetic
screening is also done at this step only in ivf lab. Once the embryos are
created in ivf lab, after 2-3 days until the cells have divided and the embryo
consists of about eight cells, they are tested for any chromosomal
abnormalities. A trained embryologist removes one or two of the cells
(blastomeres) from the embryo. The
chromosomes are examined to see how many there are and whether they are normal.
One, two or three of the embryos without abnormal numbers of chromosomes are
transferred to the womb so that they can develop. Any remaining unaffected
embryos can be frozen for later use.
Hence the ambience required for embryos to grow must be of high and standard
quality. Air quality, particle count and sterility are extremely important in
an IVF laboratory to ensure best clinical outcomes. Human embryos are extremely
sensitive to the presence of any smells, Volatile Organic Compounds (VOC),
Chemically Active Compounds (CAC). The minimal requirement for any laboratory
offering ART is to implement a quality control system for all the
embryologists. It has been proved that air quality is crucial for the success
of IVF because of the presence of volatile organic compounds (VOCs), microbes,
and perfumes, all of which can be harmful to embryo development in vitro.
Therefore IVF laboratories are equipped with high efficiency particulate air
(HEPA), and activated carbon filters plus positive pressure for air particulate
control, with or without CODA system.
The requirement of embryos to develop in the IVF laboratory in the initial
stages is very crucial and important as it requires maximum care and hygienic
environment. The equipment that is used during the IVF process must provide an
optimum environment for embryos while they are growing in the lab. While the
embryos are within the incubators a proper environment is provided by a controlled
temperature and gas mixture. The gas levels and temperature of each incubator
are checked daily. The removal of the embryos from the incubator and placement
on the microscope for examination is performed only when absolutely necessary.
While the embryos are out of the incubators they are placed on surfaces that
are heated to body temperature just like the incubators. Their time out of the
incubator is for a minimal time and the air quality within the room prevents
their exposure to air borne toxins. The importance of the culture system and
how it is used to maximize growth cannot be overstated.
The clean room in an IVF Laboratory should be built in such a way that
outside contaminates cannot enter the lab. The clean room area is the most
important place as the embryos originate here and the success of the ivf cycle
and in turns PGS depends on it. Experience of Fertility specialists, Fertility
embryologists and the scientists are the key factors to be kept in mind while
setting up a state-of-the-art IVF lab. You need IVF lab designer, who are
driven by passion of success to ensure continuous development and delivery of
State of the ART IVF Projects.
Quality is the Key to Reliable IVF procedures. Shivani Scientific Industries
(P) Ltd. is highly focused company on Assisted Reproductive Technologies and
Bio-Medical Equipments with proven track record of over 42 years. Shivani has
contributed into development of ART field in India significantly. We supply
complete range of IVF laboratory consumables and IVF laboratory equipment such
as laminar flow work stations, anti vibration tables, temperature controlled
equipment and air filtration equipment. We represent 26 International Companies
into India. We also have our own Fornax range of innovative IVF products which
are exported to more than 30 countries. We specialises in providing Turnkey
Project Services for setting up of IVF Labs, OT rooms, ICU, CCU, NICU complying
to various regulatory standards. We have recently started a new Division for
IVF consumables which brings world class products such as Wallace range of
medical devices and Life Global range of Culture Media. Amongst other brands
are NUNC, MTG, Fornax, purten & graf, Merck, GMS, Blue star, RI consumables
You are Welcome to the world of Shivani Scientific where end to end
solutions are provided for enabling life through technology at http://www.shivaniscientific.com/
or at http://ivfworld.wordpress.com
You can contact us on 91 22 2896 1768 to inquire about any IVF laboratory
equipments and consumables.